This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.African American are at risk to suffer severe consequences of hypertension. Despite excellent blood pressure control and despite use of reno-protective antihypertensive medication, hypertension-related renal disease commonly progresses. The African American Study of Kidney Disease and Hypertension (AASK) was a long-term multi-center, prospective, randomized double-blinded trial to determine the effects of blood pressure control levels and the use of specific anti-hypertensive regimens on the progression of renal insufficiency in African Americans with hypertensive nephrosclerosis. The AASK was the first large-scale study of its kind, and the intervention part of the study was recently and successfully completed. The AASK study demonstrated that the incidence of clinical endpoints and the progression of kidney disease were high in the African American subjects, even in the group that received the most effective therapy. Therefore, the AASK Cohort study is designed to determine prospectively the long-term course of kidney function and risk factors for kidney disease progression in African Americans with hypertension-related kidney disease that are provided optimal therapy to control blood pressure. A secondary objective of the Cohort study is to determine the occurrence of cardiovascular disease and assess its risk factors in the setting of hypertension-related kidney disease. It is anticipated that the AASK Cohort study will provide data that enhance the understanding of the processes that determine progression of renal disease. Successful completion of this study might ultimately lead to new prevention strategies that delay the onset of end Stage renal disease.
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