The objective of this is to elucidate the mechanism by which left ventricular mass regression improves relaxation by defining its effects on myocardial perfusion reserve and mechanical efficiency; and to determine the effect of LV mass regression on functional capacity. Hypertensive patients with LV hypertrophy will undergo baseline blood (serum electrolytes, lipid profile, and complete blood count) and urine tests, followed by PET scan, cardiopulmonary exercise, and 3D echocardiography. They are then started on a full year of treatment for hypertension with periodic blood tests, urine, electrocardiograms, 3D echocardiograms to monitor LV mass regression. After the year of treatment, the PET study, stress test and 3D echo are repeated once while on blood pressure medication, and once again after a closely monitored period of medication washout.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
29
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
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