Women with systemic lupus erythematosus (SLE) have a 25% rate of miscarriage. Factors postulated to contribute to this high loss rate include 1) the overall activity of SLE 20 renal disease 3) placental thrombosis from a hypercoagulable state (measured by the lupus anticoagulant and anticardiolipin antibody and 4) poor prior obstetric history.
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