The primary objective of the protocol is to study the effect of the drug sulfisoxazole on the diuretic effect of furosemide in patients with nephrotic syndrome vs healthy volunteers. For this study, 12 patients with nephrotic syndrome but normal renal function and 8 healthy volunteers will be admitted to the GCRC. The metabolic diet from the GCRC contianing a very low amount of sodium for three days as an outpatient. This diet will reduce the cahnces of swelling coming back inspite of stopping the diuretic in patients with nephrotic syndrome. Subsequently the subjects will be admitted to the GCRC and continue the metabolic diet. For this study subjects will be asked to consume a diet that has a known amount of salt and water. When the kidney's salt output matches the amount of salt that the subjects are recieving in the diet we will begin the actual experimentation phase of the study. We expect it to take approxiamtely 2-3 days to achieve sodium balance once a patient is admitted to the GCRC.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
26
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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