Age-related osteoporotic fracture is in large part due to the reduction in bone strength that occurs with age. About 80% of the variance in bone density, which is the main determinant of bone strength, is due in whites to heritable factors. Although it is known that blacks have a higher bone density and lower fracture incidence than whites, heritability of bone strength has not been studied in blacks. Identification of the genes responsible for determining bone strength within and between blacks and whites would represent a major step in early identification of population at risk of fracture and in developing new approaches to preventative and therapeutic regimens for age-related osteoporosis.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000750-27S3
Application #
6291196
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
27
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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