Malignant cells have the ability to develop resistance to cytotoxic chemotherapy. Once such mechanism is through the development of resistance to several classes of chemotherapeutic agents, including the anthracyclines, taxanes, epipodophyllotoxins and vinca alkaloids. This resistance prototype is called the multidrug resistance phenotype (MDR). The resistance is conferred through the presence of a glycoprotein pump that serves to eliminate certain chemotherapeutic agents from the malignant cell. LY335979 is an agent that has been shown in in vitro cell culture models to inhibit the MDR pump, p-glycoprotein. This study is the first attempt to expose humans to LY335979 in its intravenous form and to characterize its toxicity and pharmacokinetic profile. This is a nonrandomized study of LY335979 and doxorubicin in patients with histologically or cytologically documented malignancy who have failed conventional therapy or whose disease is considered refractory to standard chemotherapeutic regimens or for which no standard chemo- therapy is available.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000750-27S3
Application #
6291140
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
27
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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