This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal describes a study to evaluate the efficacy of oral bisphosphonate therapy for adults with Osteogenesis Imperfecta (OI). OI is a heritable disorder of collagen synthesis. Affected persons have low bone mineral density and experience multiple fractures and progressive bony deformity. To date, no effective therapy exists for this debilitating condition. Improvements in bone mineral density and in fracture rates in a small number of patients treated with bisphosphonates have been reported. The efficacy of oral bisphosphonate has not been established. We will characterize the changes effected by oral bisphosphonate therapy and compare the efficacy of daily versus weekly dosing of oral bisphosphonate in adults with OI.
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