This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This observational prospective study is examining the clinical and immunologic progression in asymptomatic HIV-infected subjects after they stop antiretroviral therapy. The objectives are to determine the importance of virologic, immunologic, and host factors as predictors of subsequent disease progression. Subjects will stop taking their anti-HIV drugs and have blood evaluations monitored for viral load and CD4/CD8 cells. In addition, body measurements and skill and memory tests will be completed. If CD4 cell counts are low or subjects present with an AIDS-defining illness, they will be encouraged to restart anti-HIV drugs. If subjects restart drugs, they will begin part two and be asked to complete study visits until they have been on medications for about six months or on-study for about two years, whichever is longer. Approximately 158 subjects will be enrolled in this multi-center study with about 10 subjects participating at the IU site.
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