This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This is a pilot phase I study of decaffeinated green tea concentrate combined with Capsicum vanilloid and available commercially as a nutriceutical, Capsibiol-T. It will be done in four patients with either metastatic melanoma or metastatic renal cell cancer. The purpose is to obtain pilot clinical and pharmacokinetic data in human cancer patients with the commercially recommended (or slightly higher than recommended) dose. Blood levels of the the presumptive active ingredients of green tea will be measured asa well as levels of VEGF and NO. It is hoped that this pilot data will serve as a basis for a future grant application.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000750-36
Application #
7717557
Study Section
Special Emphasis Panel (ZRR1-CR-8 (01))
Project Start
2007-12-01
Project End
2008-05-31
Budget Start
2007-12-01
Budget End
2008-05-31
Support Year
36
Fiscal Year
2008
Total Cost
$305
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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