This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine if insulin sensitivity in skeletal muscle is diminished in polycystic ovary syndrome, if the decreased insulin sensitivity is intrinsic (non-acquired) in etiology, and if reduction of insulin resistance with an insulin sensitizer will restore the physiologic role of insulin in ovarian reproductive function
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