This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Examine the indirect effects of medicinal cannabis on objective and subjective sleep quality and quantity in HIV positive patients with painful neuropathy. Determine if daytime medicinal cannabis treatment will be associated with increased nocturnal sleep efficiency, increased slow wave sleep and decreased percentage REM sleep compared to placebo. Determine if daytime cannabis administration will be associated with improved subjective nocturnal sleep quality compared to placebo. Specific changes will include decreased sleep latency, increased total sleep time, and increased global sleep quality.
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