This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This pilot and feasibility proposal focuses on the relationship between adiponectin and cardiovascular disease (CVD) risk factors in obese Mexican American and African American children. A better understanding of predictors of CVD in high risk populations may enhance efforts at prevention and early intervention. The overarching hypothesis is that single nucleotide polymorphisms (SNPs) in the genes coding for adiponectin and the adiponectin receptors are associated with CVD risk factors in obese children. We further hypothesize that these associations are modified by both race and ethnicity. There are large gaps in our understanding of how CVD risk factors cluster in children. However, these patterns are known to be influenced by race and ethnicity. For a given body weight the total amount of fat and its distribution throughout the body differs for white, black and Hispanic children. Similarly there are differences in these groups with regard to insulin sensitivity, dyslipidemia, and blood pressure. Growing evidence suggests that adiponectin may mediate each of these physiological and biochemical disturbances. Using a cross-sectional design, we will study a minimum of 120 subjects from a minimum of 20 families each with at least one obese child.
AIMS 1. To recruit obese Mexican American and African American children and their families for gene association studies 2. To phenotype CVD risk factors in obese children and their families 3. To collect DNA from obese children and their families 4. To genotype SNPs in the genes coding for adiponectin and the adiponectin receptors 5. To test the hypothesis that SNPs in adiponectin and adiponectin receptor genes correlate with CVD risk factors in obese children
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