This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Justification for Expedited Level of Review:This protocol qualifies for expedited review. It presents no more than minimal risk to human subjects, and involves only procedures listed in categories 4 (collection of data through noninvasive procedures), 5 (research involving materials (medical records) that have been collected or will be collected solely for nonresearch purposes, and 7 (research on individual characteristics or behavior including cognitive and motor development).Myelination within the brain is a dynamic process that occurs throughout childhood and adolescence. Strucural neuroimaging studies have shown patterns and rates of global and regional volumetric changes across the life-span. Additionally, diffusion tensor imaging studies (DTI) have reported changes in white matter structure and integrity across the life-span. More recent studies have combined these approaches from a neurodevelopmental perspective to investigate brain-behavior relationships as a function of brain maturation.
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