The nature of the feedback regulation of ACTH release by cortisol will be tested in normal men. We will administer a potent inhibitor of adrenal steroidogenesis before and then with concomitant pulsatile or continuous intravenous delivery of cortisol over 24hr. This will tell us if a pulsatile cortisol signal shuts off ACTH secretion more efficiently.

Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Virginia
Department
Type
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
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