The nature of the feedback regulation of ACTH release by cortisol will be tested in normal men. We will administer a potent inhibitor of adrenal steroidogenesis before and then with concomitant pulsatile or continuous intravenous delivery of cortisol over 24hr. This will tell us if a pulsatile cortisol signal shuts off ACTH secretion more efficiently.
Showing the most recent 10 out of 674 publications