This study will examine whether low doses of vaginal estradiol exert only local effects on the vaginal and urethral mucosa without systemic absorption of estradiol; so that symptoms of urogenital atrophy are improved without side effects of systemic therapy (i.e. potential risk of breast cancer). Twenty-five postmenopausal women with urogenital atrophy will be studied, 5 in each cohort. The five cohorts will be as follows: 10 mcg, 5 mcg, 2.5 mcg and 1.25 mcg doses and placebo. Plan to complete study.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
25
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Virginia
Department
Type
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
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