This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent evidence suggests that a mixed meal induces skeletal muscle vasodilation, including the recruitment of new blood vessels. This dilation is probably a result of increased insulin secretion after the meal. Resistance to insulin's vascular effects after elevation of plasma fatty acids, may contribute to the metabolic derangements seen in Type 2 DM, obesity and hypertension. The method of measurement of microvascular volume in the skeletal muscle of humans is currently unique to the University of Virginia. In our protocol, we will study total blood flow and capillary recruitment in the forearm, and whole body glucose utilization of 22 lean adults before and after a measured mixed meal, once receiving an Intralipid/heparin, and once without the infusion. We will make these measurements using Doppler U/S and microbubble contrast-enhanced ultrasound.
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