Abstract

Members of pedigrees with ACTH resistance to determine whether ovine CRH (oCRH) stimulation testing is useful for discrimination obligate heterozygotes for this disease from normal individuals. Subjects from two previously characterized pedigrees will receive a single intravenous bolus of synthetic OCRH with subsequent timed blood sampling for 3 hrs. These studies will be useful for genetic counseling and provide insight into normal regulation of the hypothalamic-pituitary axis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000865-23
Application #
5221708
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
23
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139
Bei, Bei; Seeman, Teresa E; Carroll, Judith E et al. (2017) Sleep and Physiological Dysregulation: A Closer Look at Sleep Intraindividual Variability. Sleep 40:
Stepanikova, Irena; Oates, Gabriela R; Bateman, Lori Brand (2017) Does one size fit all? The role of body mass index and waist circumference in systemic inflammation in midlife by race and gender. Ethn Health 22:169-183
Sin, Nancy L; Ong, Anthony D; Stawski, Robert S et al. (2017) Daily positive events and diurnal cortisol rhythms: Examination of between-person differences and within-person variation. Psychoneuroendocrinology 83:91-100

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