This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
Specific Aim #1 To investigate physical activity, body fatness and cardiopulmonary fitness in children previously treated for ALL We hypothesize that decreased physical activity is related to increased body fatness and decreased cardiopulmonary fitness in children previously treated for ALL. This pilot study aims to recruit 40 children, 6 to 13 years of age, who have achieved remission after treatment for ALL. Body fatness will be assessed by body mass index (BMI), anthropometry and bioimpedance. Dietary intake will be evaluated by a food frequency questionnaire. Other causes of obesity and physiologic limitations to physical activity, such as endocrine abnormality, will be assessed by review of medical records. Cardiopulmonary fitness will be evaluated by exercise testing. Physical activity will be measured by an activity monitor. We will correlate physical activity with fatness and fitness measures while taking into account dietary and clinical variables using multiple regression.
Specific Aim #2 To evaluate psychosocial barriers to physical activity in children previously treated for ALL Psychosocial barriers to physical activity will be assessed by examining behavioral and attitude variables of the child and parents separately. The child will complete a Physical Activity Determinants questionnaire to identify psychosocial influences on physical activity. The parents will complete two questionnaires: Child Vulnerability Scale and Parent Protection Scale. Results of the questionnaire surveys will be analyzed and correlated with physical activity measured by activity monitor.
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