This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Objective To estimate the proportion of women who develop viral rebound at 24 weeks postpartum compared with the third trimester. NOTE: Third trimester viral load is defined as the average (on the log10 scale) of plasma HIV-1 RNA at 34 and 36 weeks gestational age. If one of the two viral loads is missing, the other value will be used. Viral rebound is defined as an increase in plasma HIV-1 RNA of 0.7 log10 from viral load at the third trimester. If one of the gestational weeks 34 and 36 viral loads is < 50 copies/mL and the other is 50 copies/mL, viral rebound is defined as an increase of 0.7 log10 from the average using 50 copies/mL imputed for the < 50 copies/mL result. If the subject's viral load is starting at < 50 copies/mL, rebound is defined as an increase to 500 copies/mL.
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