This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
The aim of this study is to explore the relationship between depression, activities of daily living, and executive function in patients with Alzheimer's disease (AD) at the 10 Alzheimer's Disease Research Centers of California (ARCC). Naturalistic information regarding the current treatment of depression in dementia will be gathered. The relationship of caregiver mood to patient depression and quality of life will be studied. The ability of AD patients to self-report depressive symptoms will be determined and new tools for assessing depression in dementia developed. This research project will provide information on the ability of the ARCC's to identify a population of patients with dementia and depression preparatory to developing a clinical trial of antidepressant pharmacotherapy of depressive symptoms in dementia.
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