This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
SPECIFIC AIMS 1. Acute Hormonal Changes after Aneurysmal SAH - To define the rate and risk factors of anterior pituitary dysfunction after aneurysmal SAH, particularly regarding corticotroph and somatotroph function. 1A. Risk Factor Assessment: Risk factors for corticotroph (adrenal) and somatotroph insufficiency acutely after SAH include: 1) poor clinical Hunt and Hess grade, 2) advanced age, 3) hypotensive and hypoxic insults, 4) anterior circulation aneurysm location, 5) large amount of SAH (high Fisher grade), and 6) anterior circulation vasospasm. 1B. Vasospasm and somatotroph function: Patients with somatotroph insufficiency after SAH have a higher incidence of clinically significant cerebral vasospasm than patients without somatotroph insufficiency. 2. Chronic Hypopituitarism after Aneurysmal SAH - To define the rate and risk factors of chronic anterior pituitary insufficiency after aneurysmal SAH. 2A. Risk Factor Assessment: Risk factors for development of chronic anterior pituitary insufficiency after aneurysmal SAH include: 1) poor clinical Hunt and Hess grade, 2) advanced age, 3) hypotensive and hypoxic insults, 4) anterior circulation aneurysm location, 5) large volume of SAH blood (high Fisher grade), and 6) anterior circulation vasospasm. 2B. Relationship of hypopituitarism to neurobehavioral outcome: Patients diagnosed with untreated hormonal deficiency will have a higher rate of neurobehavioral and quality of life complaints than patients without hormonal deficiencies.
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