Abstract

Repeated administration of long-acting hallucinogens rapidly elicits tolerance to their psychological effects. N,N-Dimethyltryptamine (DMT) is a very short acting endogenous hallucinogen & drug of abuse, tolerance to which has never been demonstrated in humans. We will attempt to develop tolerance in a pilot group of three subjects by gradually increasing doses and frequency of administration of 4 consecutive doses, and then studying 12 experienced hallucinogen users using repeated placebo and repeated DMT on 2 separate days.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000997-19
Application #
3765902
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of New Mexico
Department
Type
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131

  Publications

Duggan, Catherine; Baumgartner, Richard N; Baumgartner, Kathy B et al. (2018) Genetic variation in TNF?, PPAR?, and IRS-1 genes, and their association with breast-cancer survival in the HEAL cohort. Breast Cancer Res Treat 168:567-576
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445
Di Fiore, Juliann M; Martin, Richard J; Li, Hong et al. (2017) Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort. J Pediatr 186:49-56.e1
Parvez, Faruque; Medina, Sebastian; Santella, Regina M et al. (2017) Arsenic exposures alter clinical indicators of anemia in a male population of smokers and non-smokers in Bangladesh. Toxicol Appl Pharmacol 331:62-68
Denson, Lee A; McDonald, Scott A; Das, Abhik et al. (2017) Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants. Am J Perinatol 34:240-247
Harmon, Molly E; Lewis, Johnnye; Miller, Curtis et al. (2017) Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities. J Expo Sci Environ Epidemiol 27:365-371
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628
Williams, Robert C; Elston, Robert C; Kumar, Pankaj et al. (2016) Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND). BMC Genomics 17:325
Harmon, Molly E; Campen, Matthew J; Miller, Curtis et al. (2016) Associations of Circulating Oxidized LDL and Conventional Biomarkers of Cardiovascular Disease in a Cross-Sectional Study of the Navajo Population. PLoS One 11:e0143102

Showing the most recent 10 out of 568 publications