This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This study is a proton magnetic resonance spectroscopy (1H-MRS) investigation of a group of children aged 6 to 18 years of age soon after mild to severe traumatic brain injury (TBI). This purpose of the study is to provide an understanding of the temporal relationship between acute brain changes and long-term (1 year) outcome assessed by detailed neuropsychological testing. The current diagnostic methods to measure the type and extent of injury and predict outcome are insensitive to cellular processes that are fundamental to TBI. The goal of the study is to monitor the integrity of neurons following TBI, thereby establishing a relationship between neurometabolism and neuropsychological outcome. This may provide insight into clinical management, prediction of outcome and help determine the effectiveness of therapeutic options.
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