This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.We propose to examine whether a speicific common genotype of community-acquired MRSA (USA 300 strain) is associated with a different length of colonization from the associated with nosocomial strains of MRSA (non-USA 300 strains). We also propose to examine whethr the risk factors for prolonged colonization with strain USA 300 MRSA are the same as those for prolonged colonization with non-stain USA 300 genotypes.We will also compare rapid PCR technique to standard culture techniques for the identification of MRSA in patients with a prior history of colonization of infection with both nosocomial and community-acquired strains of MRSA. To date, clinical studies with rapid PCR to date have focused on testing samples from patients known to be colonized with healthcare-associated MRSA strains. To our knowledge, rapid PCR has not been tested in a setting where the time from initial colonization or infection to repeat testing may be prolonged, nor has it been tested in the setting of community-acquired strains of MRSA.
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