This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Cystic Fibrosis (CF) is a fatal disorder caused by a mutant CF transport receptor (FGTR) gene encoding an apical membrane chloride channel. Curcumin (Cur), a compound in the spice tumeric rescued defective CFTR and improved survival in mice engineered to express CF. Cur is also a potent anti-opidant that has poor bioavailablility. The bioavailability of Cur can be enhanced using piperine (Pip), a constituent of black pepper. Cur/Pip has not previously been studied in CF patients as a potiental therapeutic agent.We will compare safety, Cur plasma pharmacokinetics, anti-oxidant, and CFTR modulatory effects of oral Cur/Pip (685mg/5mg per capsule) in CF patients and healthy volunteers (HV).

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000997-33
Application #
7716586
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-05-01
Project End
2008-11-30
Budget Start
2008-05-01
Budget End
2008-11-30
Support Year
33
Fiscal Year
2008
Total Cost
$970
Indirect Cost
Name
University of New Mexico
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
868853094
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
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