This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This secondary study (of study 06-283) is designed to test the hypothesis that ventilation and oxygenation strategies in SUPPORT will not be associated with an increase in death or brain injury (Grade 3/4 IVH by cranial US at 4-14 days ('early cranial US') or 35-42 weeks ('late cranial US'), periventricular leukomalacia at 35-42 weeks, abnormal brain MRI at 35-42 weeks). We will also use neurodevelopmental follow-up data at 18-22 months corrected age to assess comparative and combined predictive capabilities of these neurodiagnostic modalities.Hypotheses: 1)Multivariate modeling will demonstrate that conventional brain MRI at 35-42 weeks PMA will be superior to cranial US in predicting neurodevelopmental outcome at 18-22 months corrected age. 2)There will be insufficient evidence to reject the null hypothesis that no differences exist in the frequency of Death/Grade 3/4 IVH or Death/PVL on early or late US between Low and High SpO2 groups (within each randomized ventilation strategy), or between Early CPAP and Control ventilation groups (within each randomized oxygenation strategy). 3)There will be insufficient evidence to reject the null hypothesis that the frequency of Death/abnormal brain MRI at 35-42 weeks postmenstrual age (PMA) is not different between Low and High SpO2 groups (within each randomized ventilation strategy), or between Early CPAP and Control ventilation groups (within each randomized oxygenation strategy).
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