This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.
Specific Aims :1. To determine whether olanzapine is effective at reducing craving for alcohol and reducing alcohol use in a sample of alcohol dependent subjects. 2.
The second aim i s to test the putative mechanism of change by determining whether the effect of olanzapine on alcohol use behavior is mediated by the effect of olanzapine on cue-elicited craving. 3.
The third aim will be to examine whether genetic differences moderate the effects of olanzapine. [The polymorphism examined here involves the D4 dopamine receptor gene DRD, which has a variable number of tandem repeats VNTR in exon 3 Van Tol et al., 1992. The rationale for the examination of this polymorphism is discussed below in Summary of Rationale. With respect to the DRD4 VNTR, individuals with at least one copy of an allele with 7 or more repeats are hereafter referred to as DRD4 L individuals, and individuals with alleles that have fewer than 7 repeats are hereafter referred to as DRD4 S individuals.]
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