The aim of this study is to evaluate bone mass in men with prostate cancer requiring treatment with Gonadotrpin-releasing hormone agonist therapy (GnRH-a). Patients requiring GnRH-a will be compared to age-matched controls with prostate carcinoma not undergoing hormonal ablation. Skeletal integrity will be assessed by state-of-the-art bone density measurement using dual energy xray absorptiometry (DXA) of the forearm, hip, total body, hand and ultrasound of the heel. To assess biochemical parameters of bone turnover, markers of bone resorption (collagen crosslinks) and bone formation (osteocalcin and bone specific alkaline phosphatase) in addition to other assessments of bone metabolism (PTH, 25 hydroxyvitamin D, calcium) will be measured and correlated with skeletal integrity.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR001032-25
Application #
6407047
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1977-12-01
Project End
2004-11-30
Budget Start
Budget End
Support Year
25
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
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