The objective of this project is to determine whether topiramate slows disease progression in patients with amyotrophic lateral sclerosis (ALS). ALS is a progressive uniformly lethal neurodegerative disorder for which there is no known cure. Recent genetic and biochemical studies implicate glutamate excitotoxicity, free radical toxicity, and mitochondrial dysfunction as possible causes of familial ALS (FALS) and sporadic ALS (SALS) (1-10). Topiramate is a FDA approved agent for epilepsy. One mechanism of action of topiramate is to antagonize kainate activation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) glutamatergic excitatory amino acid receptor.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR001032-25
Application #
6407197
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1977-12-01
Project End
2004-11-30
Budget Start
Budget End
Support Year
25
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
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