This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this study is to analyze the characteristics of peripheral blood immune cells and measure humoral immune responses in Type 1 diabetes patients, relatives at high risk and relatives at low risk for developing Type 1 Diabetes, patients with other autoimmune diseases and normal, healthy control individuals. The study subjects' genetic analysis will include HLA typing. Specifically, but not exclusively, we will look at the role of insulin receptor positive and antigen reactive cells in the peripheral blood, with special emphasis on regulatory and other specialized cell populations,serum autoantibodies and disease predisposition.The study has the potential to find a cellular marker for human Type 1 diabetes mellitus and also to give us a better understanding of the disease process itself. The ability to monitor the activity of autoimmunity could help any future interventional tools too.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR001032-32
Application #
7606987
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
32
Fiscal Year
2007
Total Cost
$3,521
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
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