This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This is a preliminary study aimed at advancing knowledge about the clinical phenomenology, neurocognitive profiles, and pathophysiology of schizophrenia through intensive study of the pre-psychotic, prodromal phase. The primary aims of this study are as follows: 1) to prospectively characterize the clinical, neurocognitive, social-behavioral, and neuroanatomical features of the early and late prodromal phases of schizophrenia. 2) To document the nature and degree of changes in clinical, neurocognitive and neuroanatomical status over the follow-up period. 3) To determine the nature of the relationship among risk factors, specifically between prodromal clinical impairment and neurocognitive functioning. 4) To compare these phenotypes to identical measures already collected on a sizeable sample of adolescents and young adults at genetic high-risk for schizophrenia (n=40) individuals with a first-degree relative suffering from schizophrenia and without attenuated schizophrenia-like symptoms and healthy, age, sex and parental socioeconomic status matched controls. 5) To develop a recruitment infrastructure for future large-scale, longitudinal treatment and prevention studies of the prodrome to schizophrenia. This is a longitudinal study that will monitor the symptoms and experiences of adolescent and young adult subjects who are considered to be clinically at-risk for developing psychosis.
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