This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This is a cross-sectional observational study of individuals who have been awarded the Joslin fifty year medal. Joslin's Medal Program recognizes individuals who have lived with insulin-dependent diabetes for 25, 50 and 75 years with special awards to commemorate their dedication to lifelong diabetes management. Approximately 400 subjects are expected to enroll in the study based on previous interest and the number of expected Medalists. There are three specific aims of the study, the first of which is to document the clinical evidence of micro and macrovascular complications associated with diabetes (neuropathy, nephropathy, retinopathy, and cardiovascular disease). The second specific aim is an examination of biochemical factors which may help in understanding why some Medalists have been able to survive without complications. The third specific aim follows on the second, to examine genetic polymorphisms which have been associated with the physiologic pathways of vascular damage. The period of data collection is expected to be two years.
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