This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Metabolic syndrome, a cluster of cardiovascular risk factors, including insulin resistance, increased abdominal girth, hypertension and dyslipidemia, is thought to be a chromic inflammatory state. TNF-alpha is an inflammatory cytokine that may downregulate adiponectin and contribute to insulin resistance.
The aims of the study are to determine the short-term effects of TNF-alpha blockade with Etanercept on inflammatory markers, adiponectin, and insulin sensitivity in patients with metabolic syndrome. The hypothesis is that TNF-alpha blockade will reduce measures of inflammation, raise adiponectin and thus improve insulin sensitivity in this patient population.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR001066-29
Application #
7374785
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2005-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
29
Fiscal Year
2006
Total Cost
$82,140
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
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