This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Androgen deficiency in HIV-infected women is associated with sarcopenia and may cause critical reductions in physical functioning. Among such women, reduced muscle mass is a major predictor of osteopenia. Furthermore, bone markers suggest relatively reduced bone formation in such patients, which may also result from diminished androgenic stimulation of osteoblast function. The effects of long-term androgen therapy on lean body mass, bone density and other clinical endpoints including quality of life, functional status, depression indices and neurocognitive function in HIV-infected women are not known. Among women with AIDS wasting, long-term testosterone administration will increase bone density and quality of life, functional status, depression indices and neurocognitive function as compared to placebo treatment.
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