Twelve prepubertal patients taking haloperidol clinically will be given deuterated haloperidol and the metabolism and distribution of the drug will be characterized over a 48 hour period. Metabolites, particularly a potentially toxic piperidine metabolite will be analyzed in picogram quantities by GC-MS EI. Pharmacokinetic and distribution parameters will be characterized in a child population.

Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
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Kelly, Clare B; Hookham, Michelle B; Yu, Jeremy Y et al. (2018) Response to Comment on Kelly et al. Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes. Diabetes Care 2018;41:120-127. Diabetes Care 41:e102-e103
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Hollis, Bruce W; Wagner, Carol L (2016) Response to commentary by D Roth. Evid Based Med 21:120
Hollis, Bruce W; Wagner, Carol L; Howard, Cynthia R et al. (2015) Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. Pediatrics 136:625-34

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