This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this study is to evaluate the safety and transfer of dietary vitamin D3 (cholecalciferol) into breast milk and to the nursing infant during high-dose maternal supplementation (6,000 IU/day) compared with the currently recommended dose of 400 IU/day for mother and 200 IU/day for the breastfeeding infant. Breastfeeding mothers and their babies may be at risk for vitamin D deficiency, even while taking prenatal vitamins. Vitamin D is important for bone formation, immune (infection-fighting) properties of the body, and normal growth and development of breastfeeding infants.A recent study at the Medical University of South Carolina by this research team suggests that when higher doses of dietary vitamin D (up to 4,000 IU/day) are given to a breastfeeding mother, mother's blood levels of circulating vitamin D increase and so does the amount of vitamin D found in her milk. Those infants whose mothers received 4,000 IU/day for up to three months had improved vitamin D status at four months of age. The data also suggest that 6,000 IU/day will result in optimal vitamin D status in both mother and her breastfeeding infant without the need for supplementation in the baby. Up to 10,000 IU/day vitamin D3 have been given safely to nonbreastfeeding adult men and women.A total of 32 mothers and infants will participate in this study.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR001070-30A1
Application #
7607152
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-08-01
Project End
2008-04-30
Budget Start
2007-08-01
Budget End
2008-04-30
Support Year
30
Fiscal Year
2007
Total Cost
$4,045
Indirect Cost
Name
Medical University of South Carolina
Department
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Kelly, Clare B; Hookham, Michelle B; Yu, Jeremy Y et al. (2018) Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes. Diabetes Care 41:120-127
Putterman, Chaim; Pisetsky, David S; Petri, Michelle et al. (2018) The SLE-key test serological signature: new insights into the course of lupus. Rheumatology (Oxford) 57:1632-1640
Hall, Jordan T; Ebeling, Myla; Shary, Judy R et al. (2018) The relationship between physical activity and vitamin D status in postpartum lactating and formula-feeding women. J Steroid Biochem Mol Biol 177:261-265
Kelly, Clare B; Hookham, Michelle B; Yu, Jeremy Y et al. (2018) Response to Comment on Kelly et al. Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes. Diabetes Care 2018;41:120-127. Diabetes Care 41:e102-e103
Bell, Katherine A; Wagner, Carol L; Perng, Wei et al. (2018) Validity of Body Mass Index as a Measure of Adiposity in Infancy. J Pediatr 196:168-174.e1
Sen, Sarbattama; Penfield-Cyr, Annie; Hollis, Bruce W et al. (2017) Maternal Obesity, 25-Hydroxy Vitamin D Concentration, and Bone Density in Breastfeeding Dyads. J Pediatr 187:147-152.e1
Wolf, Bethany J; Spainhour, John C; Arthur, John M et al. (2016) Development of Biomarker Models to Predict Outcomes in Lupus Nephritis. Arthritis Rheumatol 68:1955-63
Wagner, C L; Baggerly, C; McDonnell, S et al. (2016) Post-hoc analysis of vitamin D status and reduced risk of preterm birth in two vitamin D pregnancy cohorts compared with South Carolina March of Dimes 2009-2011 rates. J Steroid Biochem Mol Biol 155:245-51
Hollis, Bruce W; Wagner, Carol L (2016) Response to commentary by D Roth. Evid Based Med 21:120
Hollis, Bruce W; Wagner, Carol L; Howard, Cynthia R et al. (2015) Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. Pediatrics 136:625-34

Showing the most recent 10 out of 395 publications