This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The metabolic syndrome is a common problem, which is associated with cardiovascular disease. This proposal tests the null hypothesis that the degree of arterial calcification in adults with the metabolic syndrome is not related to race or to bone mineral density (BMD).
Specific Aim 1. To determine if the metabolic syndrome is associated with coronary artery calcification, we will examine the relations between coronary artery calcification score and the presence or absence of the metabolic syndrome. We will also look for the effects of association between the metabolic syndrome and race, age, lipids, history of smoking as well as levels of C-reactive protein and arterial calcification.
Specific Aim 2. To determine if coronary artery calcification is associated with lower bone mineral density (BMD) in African American (AA) and Caucasian (Cau) participants, we will examine the relationship between arterial calcification and bone mineral density in AA and Cau subjects. Taking into account the possibility of subclinical bone loss, we will also examine the relationship between markers of bone turnover and arterial calcification in the two groups.
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