Patients with neuroblastoma, or other GD2-positive malignancies are being treated with a combination of ch14.18 and GM-CSF following autologous bone marrow transplant in order to improve relapse-free survival rates and overall survival rates. This phase I study aims to determine the maximum tolerable dose of chimeric human/murine monoclonal antibody ch14.18 given in combination with standard dose GM-CSF, to determine the toxicities of ch14.18 given on this schedule to pediatric patients, and the PK behavior of ch14.18.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
17
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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