This application seeks support for five years for a General Clinical Research Center to be situated in San Antonio, which is now the 9th largest city in the United States and is the referral center for the 2-3 million people who live in South Texas. This clinical research facility will consist of 12 beds and will be located in tahe Special Diagnostic and Treatment Unit at the Audie L. Murphy Memorial Veterans' Administration Hospital, a teaching hospital of the University of Texas Health Science Center at San Antonio which is contiguous with the medical school. The current facility already contains the beds, nurses, laboratory space, equipment, dietitian and dietary aids, and office, kitchen and conference room space which is necessary for a General Clinical Research Center. This current application is designed to provide a mechanism for performing clinical reserach on non-veterans as well as veterans in this facility in such a way as to make maximal use of existing resources. This grant application is for a multi-disciplinary program in clinical research involving the Departments of Medicine, Pediatrics, Psychiatry, Obstetrics and Gynecology and Pharmacology. The 42 protocols in this proposal cover areas such as calcium, phosphorus and bone metabolism in neoplastic disease, adenosine deaminase deficiency and immunodeficiency disease, the pathophysiology of Bartter's Syndrome, pathogenesis and treatment of essential hypertension, factors influencing growth at puberty, development of new agents and methods for treating neoplastic disease, potassium and acid-base balance in renal disease, lectin receptors on normal and neoplastic human lymphocytes, the psychobiology of depression and esophageal motility.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
Project #
Application #
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Health Science Center San Antonio
Schools of Medicine
San Antonio
United States
Zip Code
Kawaguchi-Suzuki, Marina; Cusi, Kenneth; Bril, Fernando et al. (2018) A Genetic Score Associates With Pioglitazone Response in Patients With Non-alcoholic Steatohepatitis. Front Pharmacol 9:752
Hayden, Kathleen M; Baker, Laura D; Bray, George et al. (2018) Long-term impact of intensive lifestyle intervention on cognitive function assessed with the National Institutes of Health Toolbox: The Look AHEAD study. Alzheimers Dement (Amst) 10:41-48
Chao, Ariana M; Wadden, Thomas A; Gorin, Amy A et al. (2017) Binge Eating and Weight Loss Outcomes in Individuals with Type 2 Diabetes: 4-Year Results from the Look AHEAD Study. Obesity (Silver Spring) 25:1830-1837
Unick, Jessica L; Gaussoin, Sarah A; Hill, James O et al. (2017) Objectively Assessed Physical Activity and Weight Loss Maintenance among Individuals Enrolled in a Lifestyle Intervention. Obesity (Silver Spring) 25:1903-1909
Kawaguchi-Suzuki, M; Bril, F; Kalavalapalli, S et al. (2017) Concentration-dependent response to pioglitazone in nonalcoholic steatohepatitis. Aliment Pharmacol Ther 46:56-61
Johnson, Karen C; Bray, George A; Cheskin, Lawrence J et al. (2017) The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes: Results From the Look AHEAD Randomized Clinical Trial. J Bone Miner Res 32:2278-2287
Lorenzo, Carlos; Festa, Andreas; Hanley, Anthony J et al. (2017) Novel Protein Glycan-Derived Markers of Systemic Inflammation and C-Reactive Protein in Relation to Glycemia, Insulin Resistance, and Insulin Secretion. Diabetes Care 40:375-382
Beavers, Kristen M; Leng, Iris; Rapp, Stephen R et al. (2017) Effects of Longitudinal Glucose Exposure on Cognitive and Physical Function: Results from the Action for Health in Diabetes Movement and Memory Study. J Am Geriatr Soc 65:137-145
Marquez, Becky; Anderson, Andrea; Wing, Rena R et al. (2016) The relationship of social support with treatment adherence and weight loss in Latinos with type 2 diabetes. Obesity (Silver Spring) 24:568-75
Williams, Robert C; Elston, Robert C; Kumar, Pankaj et al. (2016) Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND). BMC Genomics 17:325

Showing the most recent 10 out of 600 publications