This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.OBJECTIVE: The focus of this proposal is to explore the mechanisms of action underlying motor learning. Current neuroimaging studies investigate mechanisms of action of learning by exploring the changes in regional neural activity and inter-regional activity of task-performance. Little effort has been given to studying the more fundamental changes of neural connections and synaptic weighting. The present proposal seeks to develop system-level modeling strategies for neuroimaging and to apply these novel strategies to mechanisms of action of motor learning. RESEARCH PLAN AND METHODS: Imaging studies will be performed to map task-performance strategy (measured as regional neural activity of task performance), information flow (measured as effective inter-regional connectivity during task performance), synaptic weighting (measured as task-independent effective inter-regional connectivity during the resting state), and changes in these measures before and after motor training. Task-performance strategy will be determined using functional magnetic resonance imaging (fMRI). Task-independent connectivity will be measured with concurrent transcranial magnetic stimulation/positron emission tomography (TMS/PET) and with resting-state fMRI. Structural Equation Modeling, using anatomical constraints individually defined by the TMS/PET and resting-state fMRI measurements, will be performed to investigate the effective inter-regional connectivity during task performance. Synaptic weighting measurements will be performed on the resting-state fMRI data using SEM.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR001346-26
Application #
7627564
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
26
Fiscal Year
2007
Total Cost
$19,533
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
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