This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
Specific Aims : 1. To carefully phenotype, with developmental and behavioral testing, children with ASD, their parents, and any siblings affected with an ASD. 2. To study differences in gene expression in the peripheral white blood cells of children with autism, and their parents, and compare these patterns to normal individuals, using microarray analysis. 3. To use transmission disequilibrium testing (TDT) and trios (affected children with autism and their partents), affected sib pair (ASP) analysis (if there are affected siblings), and novel Bayesian algorithms (which utilizes all data both from phenotypic analysis and from expression arrays), to perform genetic studies to look for association of ASD with candidate genes and for linkage peaks associated with ASD. 5. Using a case-control study design, to collect data on environmental factors that may influence the development of ASD, or the expression of the disorder.
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