This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Primary aim:The main objective of our interventional study is to evaluate the impact of the medication (amitriptyline) on symptoms of patients with abdominal pain of non-organic origin. Secondary aim:To examine the interaction between psychosocial traits (e.g., anxiety, depression, pain coping mechanisms, health-related quality of life) and bowel symptoms and measure the impact of therapy on those variables.Long term objective:We hope to expand the project in the future by evaluating this or other medications on physiologic variables such as visceral sensation, motor function and brain imaging and processing. This is a multi-center, randomized, double-blind placebo controlled study designed to determine if amitriptyline is useful in the treatment of children with functional abdominal pain. The study hypotheses will be tested by monitoring daily symptoms during the treatment phase and by administering questionnaires one week before and one month after initiation of treatment.
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