This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.
The aim of this study is to compare the effects of a low glycemic index (experimental) diet with those of a control diet among young adults ages 18 to 35 years in an 18-month randomized controlled trial.They hypothesis is that obese subjects receiving a low glycemic index diet will have lower body fat, decreased insulin resistance, and improvements in cardiovascular disease (CVD) risk factors after 18 months, compared with those receiving a standard diet.The study is a prospective, randomized controlled trial (RCT) with two treatment arms. Following baseline measurements, 90 subjects will be randomized to receive either a reduced glycemic load (experimental) diet or a reduced fat (conventional) diet. All subjects will receive group nutrition education and individual dietary counseling sessions during an intensive 6-month intervention period, with follow-up through 18 months. There will be 14 sessions during the first 6 months and 4 sessions during the 12-month follow-up period. Change in percent body fat from baseline to 18 months constitutes the primary endpoint; other outcome measures include insulin resistance and cardiovascular disease (CVD) risk factors. Compliance with dietary treatments will be assessed by multiple 24-hour dietary recalls. Physical activity will be assessed using a pedometer, as well as 24-hour recall methodology.
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