This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Although virtually nothing is known about the genetic basis of atopic dermatitis (AD) with a history of eczema herpeticum (EH) the evidence for a genetic basis in AD is well established, and a limited number of studies have identified allelic variants in candidate genes associated with AD. This project is designed to test for genetic determinants in this sub-phenotype of AD: ADEH+. We have chosen to focus upon EH because it is felt to represent a reasonable, 'real-life' surrogate for eczema vaccinatum (EV). Not all subjects with AD develop EH. It is unlikely that this is explained by differences in herpes simplex virus (HSV) exposure. We hypothesize that the variation in host response to herpes infection may be a heritable trait. The objective of this study is to use new genomic technologies using high-throughput genotyping and guided by gene expression profiling studies in skin samples infected with 2 different viruses (HSV and molluscum contagiosum virus [MCV]) to provide significant and novel information on the pathways responsible for the development of EH and possibly other relevant viral infections seen more commonly in AD subjects (e.g., EV and MCV).
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