Ovarian hyperandrogenism is one feature of insulin resistance syndromes. Androgens may exacerbate insulin resistnace, setting a vicious cycle of hyperinsulinism and hyperandrogenism. This study tested the insulin response to oral glucose (and indirectly the degree of insulin resistance) in subjects with insulin resistance before and six months after maintenance treatment with an oral contraceptive containing desogestrel, to see whether insulin sensitivity were improved. Desogestrel has minimal androgenic properties. At completion, the results did not show improvement in insulin sensitivity, nor any significant deterioration, based upon the serum insulin response to oral glucose. They did, however, show mild deterioration in glucose tolerance. Future studies comparing the effects on glucose tolerance using oral contraceptives with different formulations of progestins would be helpful in individuals with insulin resistance.

Project Start
Project End
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
13
Fiscal Year
1998
Total Cost
Indirect Cost
City
Houston
State
TX
Country
United States
Zip Code
77225
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Liao, George P; Harting, Matthew T; Hetz, Robert A et al. (2015) Autologous bone marrow mononuclear cells reduce therapeutic intensity for severe traumatic brain injury in children. Pediatr Crit Care Med 16:245-55
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Chappell, Cynthia L; Okhuysen, Pablo C; Langer-Curry, Rebecca C et al. (2015) Cryptosporidium muris: infectivity and illness in healthy adult volunteers. Am J Trop Med Hyg 92:50-5
Reveille, John D (2014) An update on the contribution of the MHC to AS susceptibility. Clin Rheumatol 33:749-57
Bethi, Siddharth; Dasgupta, Abhijit; Weisman, Michael H et al. (2013) Functional limitations due to axial and peripheral joint impairments in patients with ankylosing spondylitis: are focused measures more informative? Arthritis Care Res (Hoboken) 65:607-14
Ward, Michael M; Learch, Thomas J; Gensler, Lianne S et al. (2013) Regional radiographic damage and functional limitations in patients with ankylosing spondylitis: differences in early and late disease. Arthritis Care Res (Hoboken) 65:257-65
Benjamin-Garner, Ruby; Stotts, Angela (2013) Impact of smoking exposure change on infant birth weight among a cohort of women in a prenatal smoking cessation study. Nicotine Tob Res 15:685-92
Ornstein, Tisha J; Max, Jeffrey E; Schachar, Russell et al. (2013) Response inhibition in children with and without ADHD after traumatic brain injury. J Neuropsychol 7:1-11
Murthy, Vijaya; Willis, Rohan; Romay-Penabad, Zurina et al. (2013) Value of isolated IgA anti-?2 -glycoprotein I positivity in the diagnosis of the antiphospholipid syndrome. Arthritis Rheum 65:3186-93

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