This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this study is to determine the prevalence of patent foramen ovale (PFO) in patients with history of migraine headaches accompanied with neurological aura. Potential subjects will be recruited from headache clinics in the departments of Medicine and Neurology. Screening for migraine headache and neurological aura will be performed by a questionnaire. Those subjects with recurrent migraine headache syndrome and auras will be screened for PFO with transthoracic echocardiography and intravenous contrast. This is a prospective screening study to determine the prevalence of PFO, as determined by the transthoracic echocardiography, in a population of patients with migraine headache and aura.
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