This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is an exploratory analysis of the difference in the prevalence of the JC Virus in oropharyngeal secretions and blood of healthy individuals, persons with Acquired Immune Deficiency Syndroms (AIDS), and pes with progressive multifocal leukoencephalopathy (PML). Saliva and throat washings as well as whole blood samples will be taken from each group. Saliva samples and throat washings will be analyzed for JCV using polymerase chain reaction (PCR). Whole blood samples will be collected and analyzed for JCV using PCR and for the presence of JCV in peripheral blood leukocytes (PBLs) using CD4 lymphocyte counts. These measures will be used to determine whether JCV is harbored in the oropharynx, whether a correlation exists between JCV levels in the oropharynx and those in PBLs and to determine whether the level and strain of JCV shed from the oropharynx correlates with the degree of immunosuppression. It is predicted that JCV will be present in oropharyngeal fluids, the frequency of detection of JCV will be increased in patients with AIDS-associated PML compared with healthy controls and HIV-seropositive patients without PML and that higher levels of the JC Virus will correlate with increased immunosuppression.
| Reed, Rebecca G; Greenberg, Richard N; Segerstrom, Suzanne C (2017) Cytomegalovirus serostatus, inflammation, and antibody response to influenza vaccination in older adults: The moderating effect of beta blockade. Brain Behav Immun 61:14-20 |
| Abshire, Demetrius A; Moser, Debra K; Clasey, Jody L et al. (2017) Body Composition and Bone Mineral Density in Patients With Heart Failure. West J Nurs Res 39:582-599 |
| Ahmed, Zuhayer; Hafez, M A; Bari, M A et al. (2016) Pattern of anti-diabetic drugs prescribed in a tertiary care hospital of Bangladesh. Int J Basic Clin Pharmacol 5:6-12 |
| Harrison, Jordan M; Jung, Miyeon; Lennie, Terry A et al. (2016) Refusal to participate in heart failure studies: do age and gender matter? J Clin Nurs 25:983-91 |
| Nagarajan, Radhakrishnan; Miller, Craig S; Dawson 3rd, Dolph et al. (2015) Patient-Specific Variations in Biomarkers across Gingivitis and Periodontitis. PLoS One 10:e0136792 |
| Ebersole, Jeffrey L; Nagarajan, Radhakrishnan; Akers, David et al. (2015) Targeted salivary biomarkers for discrimination of periodontal health and disease(s). Front Cell Infect Microbiol 5:62 |
| Ewen, Heidi H; Chahal, Jasleen K; Fenster, Emily S (2015) A portrait of resilience in caregiving. Res Gerontol Nurs 8:29-38 |
| Alhurani, Abdullah S; Dekker, Rebecca L; Abed, Mona A et al. (2015) The association of co-morbid symptoms of depression and anxiety with all-cause mortality and cardiac rehospitalization in patients with heart failure. Psychosomatics 56:371-80 |
| Biddle, Martha J; Lennie, Terry A; Bricker, Gregory V et al. (2015) Lycopene dietary intervention: a pilot study in patients with heart failure. J Cardiovasc Nurs 30:205-12 |
| Janket, Sok-Ja; Baird, Alison E; Jones, Judith A et al. (2014) Number of teeth, C-reactive protein, fibrinogen and cardiovascular mortality: a 15-year follow-up study in a Finnish cohort. J Clin Periodontol 41:131-40 |
Showing the most recent 10 out of 232 publications
