This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The objectives of this study is to describe the pharmacokinetics of levofloxacin 750mg in ambulatory obese volunteers and in hospitalized obese patients. The pharmacokinetics of a 750mg intravenous does of levofloxacin administered to severly obese volunteers will not differ significantly from that of obese, hospitalized medical patients. Determine the following pharmacokinetic parameters of levofloxacin in ovese individuals: Cmax, Tmax, area under the concentration-time curve (AUC), volume of distribution, elimination rate, serum half-life, and urine clearance. Investigate the correlation between levofloxacin volume of distribution and actual adipose mass as determined by the whole body potassium counter in ambulatory volunteers.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR002602-22S1
Application #
7607321
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-04-01
Project End
2008-03-31
Budget Start
2006-04-01
Budget End
2008-03-31
Support Year
22
Fiscal Year
2007
Total Cost
$524
Indirect Cost
Name
University of Kentucky
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
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