Abstract

The purpose of this study is to attempt to increase the percent of fetal hemoglobin in the red blood cells of patients with homozygous sickle cell disease by treating them with a combination of hydroxyurea and recombinant human erythropoietin in escalating doses weekly.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR002635-07
Application #
3866957
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Scheuermaier, Karine; Münch, Mirjam; Ronda, Joseph M et al. (2018) Improved cognitive morning performance in healthy older adults following blue-enriched light exposure on the previous evening. Behav Brain Res 348:267-275
Tan, Jia W; Gupta, Tina; Manosroi, Worapaka et al. (2017) Dysregulated aldosterone secretion in persons of African descent with endothelin-1 gene variants. JCI Insight 2:
Apolzan, John W; Myers, Candice A; Champagne, Catherine M et al. (2017) Frequency of Consuming Foods Predicts Changes in Cravings for Those Foods During Weight Loss: The POUNDS Lost Study. Obesity (Silver Spring) 25:1343-1348
Mukhopadhyay, Sagori; Puopolo, Karen M (2017) Clinical and Microbiologic Characteristics of Early-onset Sepsis Among Very Low Birth Weight Infants: Opportunities for Antibiotic Stewardship. Pediatr Infect Dis J 36:477-481
Hundemer, Gregory L; Baudrand, Rene; Brown, Jenifer M et al. (2017) Renin Phenotypes Characterize Vascular Disease, Autonomous Aldosteronism, and Mineralocorticoid Receptor Activity. J Clin Endocrinol Metab 102:1835-1843
Bullock, B; Murray, G; Anderson, J L et al. (2017) Constraint is associated with earlier circadian phase and morningness: Confirmation of relationships between personality and circadian phase using a constant routine protocol. Pers Individ Dif 104:69-74
Klerman, Elizabeth B; Wang, Wei; Phillips, Andrew J K et al. (2017) Statistics for Sleep and Biological Rhythms Research. J Biol Rhythms 32:18-25
Rachmin, Inbal; O'Meara, Caitlin C; Ricci-Blair, Elisabeth M et al. (2017) Soluble interleukin-13r?1: a circulating regulator of glucose. Am J Physiol Endocrinol Metab 313:E663-E671
Buxton, Orfeu M; Pavlova, Milena K; O'Connor, Shawn P et al. (2017) Lack of change in glucose metabolism in eszopiclone-treated primary insomnia patients. Nat Sci Sleep 9:187-198
Juraschek, Stephen P; Miller 3rd, Edgar R; Weaver, Connie M et al. (2017) Effects of Sodium Reduction and the DASH Diet in Relation to Baseline Blood Pressure. J Am Coll Cardiol 70:2841-2848

Showing the most recent 10 out of 721 publications