EXCEED THE SPACE PROVIDED.The Clinical Research Center of the Brigham and Women's Hospital (BWH) has as its major goal theapplication of basic research knowledge to better understand, diagnose, and treat human disease. To achievethis aim, interdisciplinary patient-oriented research is carried out by members of Departments at the BWH(Medicine, Surgery, Women's Health, Neonatology, Obstetrics and Gynecplogy, and Radiology). With theestablishment of the Ambulatory GCRC for Cancer Research, the diversity of our GCRC has increased. Usersof the GRCR also include scientists at other hospital institutions in the Harvard Medical Area (Harvard Schoolof Public Health, Joslin Diabetes Foundation, and Children's Hospital Medical Center). The presence of theIntensive Physiological Monitoring (IPM) Core provides a powerful resource for BWH and Harvard Medicalarea researchers to study complex physiology in a variety of disorders. The establishment of an Imaging Corebrings to GCRC investigators a powerful new tool to unravel the physiologic and pathophysiologicunderpinnings human of health and disease. Finally, a national focus has been on understanding the molecularand genetic basis of human disease so as to provide early diagnosis and to develop novel therapeutic regimens.To this end BWH GCRC investigators have broadened their research efforts to forge collaborative ties withother institutions and their GCRC's as well aswith basic and clinical researchers in both the national andinternational communities.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR002635-24
Application #
7440326
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Talbot, Bernard
Project Start
1997-02-01
Project End
2008-05-31
Budget Start
2008-04-01
Budget End
2008-05-31
Support Year
24
Fiscal Year
2008
Total Cost
$925,131
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Scheuermaier, Karine; Münch, Mirjam; Ronda, Joseph M et al. (2018) Improved cognitive morning performance in healthy older adults following blue-enriched light exposure on the previous evening. Behav Brain Res 348:267-275
Tan, Jia W; Gupta, Tina; Manosroi, Worapaka et al. (2017) Dysregulated aldosterone secretion in persons of African descent with endothelin-1 gene variants. JCI Insight 2:
Apolzan, John W; Myers, Candice A; Champagne, Catherine M et al. (2017) Frequency of Consuming Foods Predicts Changes in Cravings for Those Foods During Weight Loss: The POUNDS Lost Study. Obesity (Silver Spring) 25:1343-1348
Mukhopadhyay, Sagori; Puopolo, Karen M (2017) Clinical and Microbiologic Characteristics of Early-onset Sepsis Among Very Low Birth Weight Infants: Opportunities for Antibiotic Stewardship. Pediatr Infect Dis J 36:477-481
Hundemer, Gregory L; Baudrand, Rene; Brown, Jenifer M et al. (2017) Renin Phenotypes Characterize Vascular Disease, Autonomous Aldosteronism, and Mineralocorticoid Receptor Activity. J Clin Endocrinol Metab 102:1835-1843
Bullock, B; Murray, G; Anderson, J L et al. (2017) Constraint is associated with earlier circadian phase and morningness: Confirmation of relationships between personality and circadian phase using a constant routine protocol. Pers Individ Dif 104:69-74
Klerman, Elizabeth B; Wang, Wei; Phillips, Andrew J K et al. (2017) Statistics for Sleep and Biological Rhythms Research. J Biol Rhythms 32:18-25
Rachmin, Inbal; O'Meara, Caitlin C; Ricci-Blair, Elisabeth M et al. (2017) Soluble interleukin-13r?1: a circulating regulator of glucose. Am J Physiol Endocrinol Metab 313:E663-E671
Buxton, Orfeu M; Pavlova, Milena K; O'Connor, Shawn P et al. (2017) Lack of change in glucose metabolism in eszopiclone-treated primary insomnia patients. Nat Sci Sleep 9:187-198
Juraschek, Stephen P; Miller 3rd, Edgar R; Weaver, Connie M et al. (2017) Effects of Sodium Reduction and the DASH Diet in Relation to Baseline Blood Pressure. J Am Coll Cardiol 70:2841-2848

Showing the most recent 10 out of 721 publications